At what point do you take your initial out in crypto?

I think this is where a lot of people screw themselves. They buy fine, but when a position runs they either:
\- never trim
\- trim too early
\- or round-trip gains because they never had an actual plan

How do you all think about it?

Do you take your initial out at a certain multiple?
Trim by percentage?
Wait for target allocations?
Or just hold and accept the drawdowns?