How do you prioritize contributions to taxable brokerage account vs maxing tax deferred accounts?

Some background:

I think it's highly likely I'll need to relocate within 5 years to another city for a job. Some equity built up in our current house, but move is likely going from our LCOL area to a HCOL area so equity may be insufficient for a downpayment.

In this sort of situation, would you trim back on tax-advantaged retirement savings in favor of investing more in a taxable brokerage (even if it's only in SGOV due to the time horizon)?