Does it ever make sense to realize gains if I’m going to keep investing in a single stock?

Most of my portfolio is held in ETF’s/Mutual funds, but I got relatively lucky with a stock. I’m up around 200% on short term gains, but it’s a company I want to keep investing in. I saw Kevin O’Leary say in an interview he will realize gains to “lock in his gains,” does that actually make any sense?